Preventable birth injuries are rare. At the University of Minnesota Medical Center (UMMC), they happen just 0.3 percent of the time, or to about four babies out of 2,700 deliveries each year. “But even if you
only have 0.3 percent,
that’s still four babies
a year.” says Becky Gams
Department experts examine the role of genetics in ovarian cancer. As physician-scientists in the University of Minnesota’s Department of Obstetrics, Gynecology,
and Women’s Health continue to search for better ways to treat ovarian cancer, they’re
working to capitalize on what’s already known about the disease to head it off.
University of Minnesota cancer biologist
Sundaram Ramakrishnan, Ph.D., are working on a way to stop
ovarian cancer from spreading. They’ve been investigating the
role of protein
and how they interact with
ovarian tumor cells. The team
recently has found a way to inhibit the
growth of blood vessels and keep tumors
from growing larger.
Woman finds comfort in a physician who’s willing to consider
alternative solutions to health problems. Karen Studders knows her way around a
doctor’s office. A cancer survivor who struggled for
years with fibroids, heavy bleeding, and anemia,
Studders has seen a few physicians in her day.
Carrie Terrell, M.D., considers herself a bit of
a late bloomer. The director of the department’s
Division of Obstetrics and Gynecology and new
chief-of-staff-elect for the entire University of
Minnesota Medical Center medical staff, Terrell
also was one of the department’s “Top Doc” by St.Paul
Magazine.
The Department of Obstetrics, Gynecology,
and Women’s Health is promoting a checklist to
help patients and their physicians identify “red
flags” in their family history that might warrant
genetic testing.
This fall our Department of Obstetrics,
Gynecology, and Women’s Health will mark a
major milestone: We’ll be celebrating 40 years
of sharing our latest research findings at our
Autumn Seminar.
Health-care professionals and patients partner up to advance
medical knowledge. The most important contributors to health research are the
patients who participate in research studies. They are not only learning about and accessing leading-edge treatments, says Linda Carson, M.D., “these
women are contributing to scientific knowledge,” she says.
Benefactors gave a recordshattering
$122.2 million to healthfocused
research, education, and
service through the Minnesota
Medical Foundation in fiscal year
2008. The previous record was
$78.3 million in fiscal year 2005.
On the whole, Daniel Landers, M.D., has
a rewarding job. A maternal-fetal medicine
specialist, or perinatologist, Landers sees many
patients go from heartbreaking loss to healing
and joy. “Most people who have a bad outcome with
a pregnancy are able to have a good outcome in
the future.”
When Thomas Carrier, M.D.,
joined an obstetrics and gynecology
practice in Minnesota in
1966, he and his wife, Anne,
were a little apprehensive
about how they would adjust
to life away from their
families. They are
proud to have raised their three
daughters in the dynamic Twin
Cities community.
As you’ll learn in this issue of Women’s
Health, our faculty members are deeply
involved in clinical research.We are trying
to learn whether natural killer cells can
effectively treat ovarian cancer and whether complementary and alternative
therapies can improve a patient’s quality of life.
If you’re thinking about enrolling in a clinical
research study, coming up with a list of
questions to ask your physician may seem
like an overwhelming task. Here are a few
questions to get you started.
Their names were Joseph and Isabella. They’re
the babies that sisters-in-law Lisa Eastlack and
Jennie Eastlack lost halfway through their pregnancies— the babies whose healthy younger siblings,
the women believe, are here because of maternalfetal
medicine specialist Daniel Landers, M.D.
On his first day of medical school at Duke
University, he had to fill out a questionnaire
about his professional interests. “I said the only
things of question were ob-gyn and oncology.
Here I am 15 years later as a gynecologic
oncologist,” says Argenta, an assistant professor
in the Department of Obstetrics, Gynecology,
and Women’s Health.
In fiscal year 2007, nearly
one-third of all health-related
gifts to the University of
Minnesota through the
Minnesota Medical Foundation
were designated for research.
One of the privileges of being a physician
at an academic institution is working with the
next generation of obstetricians and gynecologists.
As you’ll learn in this issue of Women’s
Health, our Department of Obstetrics,
Gynecology, and Women’s Health runs
a residency program that trains future
doctors for women.
From the University’s research hospitals to urban county hospitals to suburban private settings,
new physicians in the residency program
work in a variety of environments. The diversity in training sites—residents have rotations at six different hospitals.
To honor their parents, Leslie Turner, Fritz
Corrigan, and Nancy Woodrow have endowed
a fund for resident research. The three
siblings have seen how the state has benefited
from the U of M’s many areas
of expertise. With their gifts to the Fritz and
Mary Corrigan Resident Research Fund.
Since the 1950s, the Pap test has dramatically reduced rates of cervical cancer in the United States. But
many American women—and millions more throughout the world—don’t have Pap test screenings. In fact,
in many developing countries, cervical cancer is still the leading cause of cancer-related death for women.
Emphasizing the positive is a credo with
McGahee. Diagnosed in May 2005 with advanced
ovarian cancer, she had surgery that month and
then again two years later, when the cancer
returned. “Dr. Argenta said, ‘Part of it is your outlook on
life.’ I just haven’t gotten depressed.
“I said, ‘I want to go to the best hospital to have
this done. I’ll go anywhere; I’ll travel out of the
state. I want the best chance possible: I have three
children at home,” 38-year-old Paulus says. “And
he suggested Dr. Judson. “Eight months later, Paulus and her husband have no doubts that she found the right
physician.
Family supports research into earlier detection of ovarian cancer After Mary Wiser was diagnosed with
ovarian cancer, she sat in the office of a prominent
male doctor and asked a pointed question. “She asked, ‘If men had ovaries, do you
think we’d know more about ovarian cancer?’”
When she was a medical student, Patricia
Judson, M.D., was leaning toward a career in
perinatal genetics and maternal-fetal medicine.
Then in 1992—the year she graduated from the
University of Minnesota Medical School—her
father was diagnosed with lung cancer.
Every day my colleagues and I work to keep
women of all ages healthy. As faculty members
in the University’s Department of Obstetrics,
Gynecology, and Women’s Health, we are
approaching these issues from three angles.
We care for women with a range of health concerns.
For a limited time, special income tax
incentives make charitable giving more appealing
than ever for donors who are 701/2 or older. These
donors now can make charitable contributions
from their individual retirement accounts (IRAs)
without adverse tax implications.
From adolescence to menopause, women of all ages turn to
University physicians for expert care. When one of her young cancer patients wants to have a baby, Rahel Ghebre, M.D., will send her to colleague Kirk Ramin, M.D., who specializes in high-risk pregnancy.
While working as a full-time clinician at Women’s Health Consultants an independent practice affiliated with Abbott Northwestern Hospital she was chair of the hospital’s obstetrics and gynecology department. She then became medical staff president for Abbott and later chaired the quality committee while serving on the Allina Hospital.
Melissa Geller, M.D., was a second-year fellow at the University of Minnesota when she first fully grasped the need for quality patient education materials for women with ovarian cancer. “There is so much unknown at the time of diagnosis so much fear and anxiety that accompanies it.”
The Department of Obstetrics Gynecology and Women’s Health has honed in on technology to improve the way it cares for patients and educates students and residents. As a part of the University’s Academic Health Center the department and its faculty members have benefited from colleagues in bioengineering and information technology.
What’s the connection between miscarriage and inactivation of the X chromosome? That’s what Tracy Prosen M.D. assistant professor in the Division of Maternal-Fetal Medicine hopes to find out. Women have two X chromosomes in every cell but as female embryos develop in utero.
Under the guidance of professor June LaValleur M.D. we have begun to develop a set of virtual patient scenarios to teach our residents and students about some common women’s health issues they’ll face in their real-life patient interactions. There is also website project that will provide health information to women in Minnesota and beyond.
When 77-year-old Nancy Lindberg was diagnosed with uterine cancer in 2005 she took the news in relative stride. Her disease was at a low level—stage 1—and she felt she was blessed with “good genes and a good strong body.” When surgical oncologist Peter Argenta M.D. suggested that she would be a good candidate for minimally invasive surgery.
Recently Barbara learned how a charitable gift annuity from the Minnesota Medical Foundation. As a part of their estate plan Barbara and her husband had invested in several certificates of deposit to provide a safe and fixed income and quick liquidity should they need it.
The Food and Drug Administration (FDA) this summer approved a vaccine to protect women against cervical cancer. The vaccine prevents infection by four strains of the human papillomavirus a sexually transmitted infection that is the most common cause of cervical cancer.
For women with advanced ovarian cancer, the National Cancer Institute (NCI) now encourages
post-surgery treatment with anticancer drugs via
two methods. These combined methods, which
deliver drugs into a vein and directly into the
abdomen, extend overall survival by about a year.
The department received a $200,000 grant
from the University of Minnesota Physicians (UMP) Interdisciplinary Program Development
Committee to fund a comprehensive planning
effort. This includes hiring a consultant to
formalize the concept for the new program,
develop a business plan, and identify outcomes
measures progress toward goals.
Novakova, an obstetrician/gynecologist from
3rd Faculty of Medicine of Charles University in
Prague, received funding to come to Minnesota
under the Proshek-Fulbright Scholarship. The
scholarship was established by the estate of
Gabriela Proshek to honor her late husband,
Charles E. Proshek, M.D.
In Japan,
counselors used the book to develop a 90-hour
certification course in infertility issues. Worldwide,
the book became the “go-to” guide for reproductive
medicine experts, physicians, genetic counselors,
and mental health professionals who wanted to
learn more about the psychological issues.
This year has been a big one so far for the
Department of Obstetrics, Gynecology, and
Women’s Health. In addition to participating
in several studies that have brought
about advances in treatments for ovarian
cancer, we have received a very generous
gift from our friend Jean McGough.
The Department of Obstetrics, Gynecology, and Women’s Health recently received the largest
private donation in its history. Jean McGough and her husband, Tom, pledged $2 million to establish
the Jean McGough and Eleanor Forliti Endowed Chair in Women’s Health in memory of Jean’s mother.
Chelsea Korsh knows the value of the statistics,
but she and her husband, Michael, have lived the
RMC’s successes. Chelsea was diagnosed with
ovarian cancer in 1997, one year before she was
married. When she was
unable to conceive “the natural way,” she consulted
the RMC’s Theodore Nagel, M.D.
A drug long blamed for causing birth
defects is now showing promise as a safe and
effective treatment for women with recurrent
ovarian cancer. A study led by gynecologic oncology
researcher Levi Downs Jr., M.D., compared the
effectiveness and safety of the drug thalidomide
used in combination with a
chemotherapy often used to treat ovarian cancer.